This episode may be inspired from the TV show Get Smart, where the main protagonists Maxwell Smart (Agent 86) and Agent 99 have to protect some precious cargo on a train, while being followed by 2 KAOS agents.
Petsburg is a parody of Pittsburgh.
Hamtrak is a parody of Amtrak.
The Petsburg Flyer is possibly a reference to the American Flyer.
This is the second time that Dudley was forced to team up with a villain; the first was Snap Dad.
This is the second time the Chameleon is shown without his Molecular Transformation Suit.
The Chameleon made a book called . It shows how he became a bad guy.
The Very Lonely Lizard This episode is the second time Kitty freaks out due to her cat instincts. She finds a railroad car filled with all sorts of cat toys and goodies, causing her to go crazy.
This is the first time that both the Chief and Keswick do not appear.
This episode reveals the fact that the Chameleon has a lack of friends.
This is the first time the Chameleon mentions poison. The second time was in A Doomed Christmas.
The device that Ollie uses to show the pictures of the D.O.O.M. Picnic resembles an iPad, a device made by Apple.
This is the second time a character (this time the Chameleon) is shown in pajamas. The first was Kitty in Cruisin' for a Bruisin'.
The Chameleon shed his skin and wore underwear, a head brace and a mud mask before going to bed. When he cuddled with Dudley, he had his skin again and was wearing the transformation suit.
The Chameleon said he sheds his skin every night, yet near the end of episode he shed his skin during the day.
When the Chameleon was holding his bug-infested headgear, he appears to have a glove on his left hand.
This is also the first time Kitty ditches Dudley for her own reasons.
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