- "Purr-fect Partners/Doom-mates" - Dudley Puppy - He strums the guitar on the show's logo and then falls off.
- "Cruisin’ for a Bruisin'/Puppy Love" - Kitty Katswell - she strums the guitar, then Dudley, on his motorcycle, accidentally knocks her out and she looks at him angrily.
- "Mall Rat/Operation: Happy Birthday" - Dudley Puppy - he strums the guitar and then explodes.
- "Toast of T.U.F.F./Share-A-Lair" - Keswick - he strums the guitar, then the guitar turns into a robot and chases after him.
- "Snapnapped/Mom-A-Geddon" - Dudley Puppy - he strums the guitar then it blasts him off like a rocket.
- "Dog Daze/Internal Affairs" - Dudley Puppy - he strums the guitar, then the guitar transforms into the Chameleon, and Dudley chases after him.
(Guitar gags in later episodes duplicate these)