In the part where Dudley was in jail he's wearing the number 86, the code number of Agent Maxwell Smart from the TV show Get Smart.
This is the second time Keswick has dressed like a villain, the first was during Snapnapped.
When Keswick showed off his evil certificate, it was signed by Dr. Doom from Marvel comics, and The Wicked Witch of the West from the film The Wizard of Oz.
The scene where Dudley leads the documentary makers into T.U.F.F. HQ shows him pass through a series of security doors and a laser grid, with secret agent-themed music playing. This is a homage to the intro sequence of Get Smart.
When Dudley gets to the command center of T.U.F.F. one can see the video game Pong playing.
Dudley seems to have more common sense in this episode probably because he wants to be great around the camera crew.
In the storyboard for this episode, The Chameleon originally wore a coat and glasses.